Skull of a Skeleton with Burning Cigarette, c.1886 (oil on canvas) by Vincent van Gogh is one of his most unusual and striking works, depicting a skeleton smoking a cigarette. It’s thought to be either an anatomy study or a satirical take on mortality. Despite its small size, this painting has become famous for its dark humor and is often referenced in popular culture, standing out as a unique piece in Van Gogh's diverse portfolio.